Benefits & Advantages of Learning a New Language with an App

Software applications, or apps, have changed how people do just about everything. We used to call a cab and use paper maps to go somewhere, for example, and now we simply tap the Uber and Google Maps icons on our phones. Apps provide a new way to learn how to cook, dance, invest, socialize, and even play a musical instrument. Apps have changed how we learn new languages too. These apps are successful because they offer benefits and advantages over other approaches to learning.

Advantages of Apps over Traditional Methods of Learning New Languages

Apps have advantages over traditional education tools when it comes to learning a new language. Prior to the digital age, for example, people could only learn languages if they had access to language resources, educators, and courses in their town. Apps allow people to learn a new language anywhere they could get an internet connection.

Choose any language or course

Most brick-and-mortar schools and colleges teach Spanish, German, French, English, and Arabic, but fewer institutes of learning offer Polish, Dutch, Japanese, Vietnamese or Malay. Apps allow you to learn nearly any language spoken on the planet.

Learn at any time

Unlike in-person courses that have a set day and time for classes, apps allow you to learn a new language at any time of day or night. Sticking to a schedule can put you at risk for attending classes when you are tired or stressed out. Using an app lets you study when you have the time and energy for optimal learning.

Go at your own pace

Falling behind the rest of the class is stressful and embarrassing. Perhaps the worst part is that, once you fall behind your classmates, it is difficult to catch up. Getting ahead of the class is also frustrating as you wait for them to catch up. Using an app allows you to learn at your own pace.

Apps offer a variety of ways to learn

Everyone learns a new language in their own way; some people learn by memorizing vocabulary while others absorb more by playing games. Apps provide a wide variety of education techniques to suit almost every learning style.

You can start speaking your new language right away

Many traditional language courses start with history and grammar, whereas language apps typically try to get you speaking the language as soon as possible. Nearly three-fourths of Babbel users say they feel capable of maintaining a small conversation in their new language after just 5 hours instruction on the app.

You can track your progress

Apps can help you track your vocabulary, the amount of time you spend studying, and other information about your learning. Many digital language programs also offer rewards systems to keep you moving forward.

You can learn what is relevant to you

In a traditional classroom environment, everyone learns the same information, whether it interests them or not. This means students have to learn words and grammar rules they may never use – those who just want to learn how to order dinner during their Roman holiday has to learn as much Italian as someone who intends to move there. Apps allow individuals to learn as much or as little of a language as they desire.

Benefits of Using an App to Learn a New Language

Apps are customizable

Doing coursework on your own schedule allows you to study when you are in the mood. The customizable features of apps also let you learn your way, and at your own pace.

Apps are fun

Many apps make a game out of learning, which takes the drudgery out of picking up a new language. Apps feature images, sound and video that are colorful, cheerful, and fast moving, so time goes by quickly.

Access to online tutors

Everyone needs a little help now and then, especially when it comes to learning a language. iTalki, Rype, Tandem, Preply, Verbling, Live Lingua, and other apps offer online tutors that help you speak the language correctly.

Apps really work

Perhaps the greatest benefit is that apps really work. In a recent study, 85 undergraduates used an app to learn Spanish. Oral proficiency, vocabulary and grammar tests showed the students had learned enough to communicate in Spanish after just 12 weeks.

While using an app is not for everyone, it is a great way for many people to learn a new language without having to sit in a classroom. Whether you prefer iPhone, Android or a different device, you can use an app to start speaking a new language today.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com
SOURCES

https://www.babbel.com/en/magazine/5-advantages-of-learning-a-new-language-with-an-app

https://www.sciencedaily.com/releases/2020/06/200609095027.htm

Benefits of Online Trivia Apps

Online Trivia Apps Have Benefits!

Online trivia apps and brain games are a lot of fun, but they can also be good for your mental health. In fact, there are not many downsides to playing trivia games – they are fun to play, give your brain a workout, offer an opportunity to interact with others, and even prompt you to continue learning. Virtual trivia games are even better, in that you can play them at your convenience rather than wait for game night.

What’s so great about trivia and brain games?

It’s just human nature – people love the thrill of knowing obscure information and having the opportunity to prove it. It turns out that there is a physiological reason for this – winning stimulates production of the “happy hormones,” dopamine, serotonin and oxytocin, which make winning feel so good. Along with feelings of pleasure, dopamine is associated with learning, memory, and motor system function. Serotonin helps regulate mood, appetite, digestion, sleep, learning ability, and memory. Also known as “the love hormone,” oxytocin helps promote empathy, trust, and bonding in relationships.

Exercise for your noggin

Trivia also serves as a form of exercise for the brain. While the brain is not a muscle, it does get stronger with use and weaker from neglect like a muscle. Collecting, storing, and recalling information is like a trip to the gym for your noodle. In one study of older adults, those who learned quilting or digital photography had more memory improvement than did the participants who just socialized or engaged in activities that required less thinking. Billions of tiny nerve cells in the brain, known as neurons, have branches that connect the cells together to create a network. Communication between these neurons allows us to think and solve problems. Learning new things strengthens the brain by making the connections between brain cells stronger; exercising your brain can also make the tiny connections multiply, so the neurons can communicate even faster.

Social interaction

Perhaps the best part about trivia games is that they connect people to one another. Cleveland Clinic says that a strong social network can serve as sources of support; it can also reduce stress, help fight depression and enhance intellectual stimulation. Research from Harvard School of Public Health shows an active social life can delay memory loss in older adults. Trivia games create a great opportunity to get the social interaction you need.

What’s Better than Old-fashioned Trivia? Online Trivia!

Trivia apps take all the hassle out and put the fun back into brain games! Traditional trivia games involve proctors, participants, and game boards or paper. They also require scoring and record keeping that can slow down the fun and provide inaccurate results. Mobile apps, on the other hand, are fast, agile, and interesting, which keeps the game rolling.

The online platform allows users to enjoy trivia games without having to secure a live proctor or find other participants. Players can start a trivia game at any time of day or night, and can always find tough competitors to keep things interesting.

Keeping score on paper is tedious, and it can leave the door open for fuzzy interpretation of answers and inaccurate results. Online trivia software checks the results and displays the high scorers’ names. The program automatically checks for correct answers, catches missed questions, and maintains legacy score information, without the need for proctors or physical files. Online trivia allows for randomization, which keeps things interesting for players. Software often allows administrators to create question banks, and to randomize the questions and multiple-choice answers.

Social interaction without crowded rooms

Online trivia games create an opportunity for social interaction without all the inconveniences of socializing with others in person. Players can answer trivia questions from the comforts of their own home, at work, during their commute, or virtually anywhere. This has become particularly important during the pandemic, which has prevented large gatherings in indoor locations.

Creating virtual trivia is also good for nearly any organization, from schools to businesses to clubs. Putting quizzes online allows organizations to quiz large numbers of people all at once and give each participant the same experience, despite locations. The virtual platform also eliminates the costs of administering and scoring printed trivia games.

Online trivia apps are the newest generation in games and brain exercises. Whether it is a standing quiz night, a private event, a fundraiser, or just a great way to have fun while keeping your brain in shape, online trivia apps have it all.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Sources

https://www.psychologytoday.com/us/blog/your-neurochemical-self/201402/the-primate-brain-likes-win-cant-always-have-it

https://www.healthline.com/health/happy-hormone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154531/

https://healthybrains.org/pillar-social

https://www.hsph.harvard.edu/news/press-releases/active-social-life-delay-memory-loss-us-elderly/

Language Apps -Best of 2021

Learn a Foreign Language App – Best of 2021

Learning a foreign language is one of the best things anyone can do to connect with others, further a career, and boost brainpower. In the old days, there were two ways to learn a new language: take a class and talk to other people. Unfortunately, the COVID-19 pandemic has interrupted classroom learning and prevented people from practicing their newfound language skills with others. The good news is that advances in technology and cell phone apps have made it easier, faster, and less expensive to learn a language in exciting new ways.

A number of language learning apps are available today, and while most language applications help build vocabulary and proper grammar for the target language, each apps provides a different approach to learning a language. Some have speech recognition to ensure proper pronunciation, for example, while others offer instruction in multiple languages. A handful has emerged as the top language learning apps.

Best Foreign Language Learning Apps of 2021

Memrise

Memrise focuses on basic translation, building understanding of the language through real life situations, and correct pronunciation. Users start by learning a few key words and phrases then watches video clips of native speakers with different speaking styles and real accents that help the user recognize the nuances of the new language. The app focuses less on grammar rules and more on giving learners the confidence to speak in their new language.

Duolingo

Duolingo improves vocabulary and grammar through daily lessons and quizzes covering vocabulary recognition, listening activities and voice-enabled speaking practice. The app motivates learners by letting them earn points, level up, get virtual currency and even compete with others.

Mondly

Mondly is a colorful app that makes learning a new language fun, but it is also a serious language program. Users can choose among 30 languages to learn; they can also select their native language from among 33 choices to make learning even easier. The app uses a combination of course materials, chatbots, instant feedback, and augmented reality (AR) to help learners master a new language.

Mondly is game-like in that users can take lessons and tests to unlock the door to the next level. A new daily lesson unlocks every 12 hours. Users who complete the entire week of daily lessons take a weekly test; learners who complete the weekly tests unlock a monthly challenge. Getting access to the next learning level is good motivation for coming back day after day.

Users who open a free Mondy account have access to seven lessons and a daily lesson under the “Hello” topic. A paid account opens up the remaining lessons under topics such as core vocabulary, family, seasons and weather, public transportation, food and drinks, and even travel, vacation activities and preparing a trip.

Babbel

Babbel offers bite-size, interactive lessons that cover words and phrases someone would use in real life, from introducing themselves to ordering food or making travel arrangements. The app makes it easy to learn enough of a language to hold a short conversation after using the app for just a few hours.

The linguists and language teachers that designed Babbel created a system tailored to the user’s native language and target language, reflecting differences in the ways language-users learn new languages – an English-speaker might learn Italian differently from a Spanish-speaker, for example, so Babbel presents slightly different lessons for each language pair.

HeyPal™ Featured Future Star

HeyPal™ is a language exchange, which is an approach based on mutual learning. The app pairs language exchange partners; each partner is a native speaker of the language the other wants to learn. HeyPal allows users from around the world to use interactive chat and social posts to learn and practice a new language.

After signup, users select their native language and choose from among 30 languages that they wish to learn. Next, users interact and practice with people who speak their target language. HeyPal also includes instant translation features, grammar and spelling assist, and engaging video tutorials.

Because users get to interact with one another and practice their language skills right away and in a comfortable, natural setting of real conversations, HeyPal is fun and immersive way to learn a new language.

No single app is perfect for every user, but using an app can help almost every learner pick up a new language without having to sit in a classroom or travel to a foreign land to practice their new skills.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Sources

https://www.memrise.com/

https://www.duolingo.com/

https://www.mondly.com/

https://www.babbel.com/

http://www.heypalapp.com/

Online Gaming & Genetic Innovation News

Frank Magliochetti News Presents:

Frank Magliochetti News is growing in scope; FMN has released two new platforms to broadcast innovations in Online Gaming and Genetics. These are two industries that Frank Magliochetti has chosen to devote his energy and expertise to.

As CEO of both ClickStream / WinQuik and Chairman and Chief Executive Officer at Designer Genomics International, Inc. Driven to achieve results in two diverse industries Frank balances his time between these projects and keeping pace at Parcae Capital Corp.

Both Innovation News sites under development. Both sites are welcoming content; if you have an innovation you’d like us to share please pass it along.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Online & Smartphone Gaming

Online & Smartphone Gaming: Today and Tomorrow

Humans have been playing games since the dawn of civilization. Games have come a long way since the Ancient Egyptians played Senet – they’ve moved from wooden boards and tokens of yesteryear to the online platforms and smartphones of today.

Games remain incredibly popular, especially since the coronavirus pandemic sent people scrounging for home entertainment that wouldn’t cost them a fortune. To fill the void, many turned to online games using their smartphones. In fact, games now account for 43 percent of all smartphone use.

Statistica reported game sales skyrocketed 63 percent in just one week back in March of 2020, suggesting that people were turning to home entertainment to fill the void created by self-isolation during the pandemic. During that same month, Steam hit a peak of 23,434,674 concurrent players, smashing their record set a week prior by more than a million players and an enormous increase over the 20 million concurrent Steam players recorded at the beginning of March.

Mobile gaming accounted for more than 58 percent of the gaming market in 2019, and the global pandemic is fueling its growth. In fact, experts think the global mobile gaming market will likely reach $165.9 billion in 2020.

Players can choose from several different types of games, including action games, adventure games, card and casino games, puzzles, role-playing games (RPGs), first-person shooter games, sports and strategy games. Trivia games are especially hot these days.

Launched by ClickStream on September 30, 2020, WinQuik is the latest and greatest entry into the online trivia market. This innovative real-time gaming platform pays users money and prizes. WinQuik pops out up to five multi-player quiz games ever day, featuring well-known hosts, including boxer/actor Pooch Hall, Emmy award-winning journalist/ documentary filmmaker/tech executive Amber Theoharis, chef/TV personality Jordan Andino, and NFL quarterback/aerospace engineer/NASA intern Joshua Dobbs.

WinQuik platform offers a wide variety of new and fascinating topics to keep the games interesting. Quiz categories include survival, crime, history, the human body, cars, food, gaming, geography and more.

Using famous hosts isn’t the only thing that sets WinQuik apart from other gaming apps – it also targets a completely different audience. Unlike apps that hope to attract fantasy players or sports betters over the long haul, ClickStream caters to those casual users who prefer spending just a few seconds to interact with a gaming platform in order to win prizes and real money. Users can get involved in as little as 20 seconds and receive their game results via push notifications.

WinQuik is also free, at least for now. ClickStream will monetize the app with corporate sponsors and advertisers.

Future of Online and Smartphone Gaming

Until quite recently, substandard graphics and slow speeds were the hallmarks of online and mobile games, particularly in comparison to games for PCs and consoles. Because of improvements and advances in technology that provide better support for graphics, though, many notable titles are making the leap from PCs and consoles to mobile platforms. League of Legends: Wild Rift and Game of Thrones: Beyond the Wall went mobile in 2020, and many other titles are set to follow. The seismic shift from PCs and consoles will likely shake up the mobile gaming market to create an entirely new experience over the next decade.

A number of factors will shape online and smartphone gaming in the near and far future.

Better graphics

Graphics are significantly more immersive and sophisticated than they were in the days of Pong and Leisure Suit Larry – today’s graphics are smooth and realistic.

Advanced VR And AR Tech

Virtual reality (VR) and augmented reality (AR) technology will play an increasingly important role in video gaming in the future, especially as the price of virtual headsets drops and their quality rises. A number of online platforms are adopting VR and AR technologies to make their games more exciting, realistic, and immersive.

5G

Slow internet speeds have been the bane of gaming since the dawn of the internet. 5G will change all that with blistering fast speeds and reduced network congestion. Download speeds of 5G will be around 10 times faster than 4G speeds, which will increase download times and accessibility.

Cloud Based Gaming

In the past, users had to store games entirely on their PCs or laptops. Hardware storage demands a significant amount of memory, of course, and this limited the potential power of the game. Local storage also limited where the users could enjoy their favorite games. Cloud-based technology changed all that – users can now play anywhere they can use their phone, and because games are now stored on expansive cloud-based servers, they are no longer limited by the size of their home computer.

It’s hard to say where we’ll be in a few years, when the pandemic is over and technology will have advanced even more, but one thing is certain – we’ll still be playing games.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Sources

https://techjury.net/blog/mobile-gaming-statistics

https://www.statista.com/statistics/1109977/video-game-sales-covid/

https://www.pcgamesn.com/steam/22-million-users

http://clickstream.technology/index.php

https://www.winquik.com/

Innovative Online Gaming Companies Seize Control in 2021

Here we go! The gaming industry is rising like a phoenix from the ashes that will be left behind from the pandemic, leaving other forms of entertainment in the rubble of 2020 watch out 2021!

It has been a tough year for many industries, as COVID-19 emptied the casinos, concert halls, bars, and other real-world entertainment venues. But as 2020 has been a bust for many industries, the year has been a financial boon for online gaming, as consumers look to spend their money and their free time from the comfort and safety of home. Mobile gaming is expected to capture $77.2 billion in revenue this year, according to Reuters, leaping 13.3 percent over 2019.

To grab a share of the revenue, though, online gaming companies must be innovative enough to attract the attention of the 2.7 billion total gamers out there. This year, some found innovation within their own game categories, such as first person shooter, online casino games, arcade games, sports games, action and adventure games, board games, and massively multiplayer online games (MMOGs or MMOs).

For example, Roblox built a platform that not only allows users to play their favorite games, such as Jailbreak and MeepCity, but to develop their own games. In just the past year, Roblox has introduced a variety of tools for their 2+ million developers, such as a translation feature that allows them to publish game titles in different languages and an upgrade that allows up to 800 simultaneous players on a server. In 2019, developers earned about $100 million in revenue through in-game upgrades and virtual goods.

Apple Arcade offered users unlimited access to more than 100 games on their iPhone, Mac, iPad, and Apple TVs for only $5 a month. While offering customers a great deal is not necessarily groundbreaking, finding new ways to make money on products they already sold is. Another power player, Minecraft Earth, brought their popular augmented reality mobile game into the real world. Users can hook up with other crafters to create small-scale masterpieces, and then take their builds into the real world.

Other online games, like Level Ex and Zwift, ventured outside their categorical comfort zones. Level Ex allows doctors to put their clinical skills to the test while earning the continuing medical education (CME) credits they need to practice. Zwift sets itself apart from Pelaton, which provides run-of-the-mill online spin classes, by turning the user’s stationary bike into a video game controller in a way that allows gamers to compete against other cyclists in massive online races.

What 2021 has in Store for Gamers

Next year’s trends will likely involve virtual reality, augmented reality, cloud gaming, artificial intelligence, mobile gambling, and different payment options, but in ways we have never seen before.

Technologically advanced gadgets will help make online gaming even more interactive and immersive. Oculus Quest 2 offers next-level hardware and redesigned controllers that are easy to set up and PC VR compatible. Some companies are looking to make their products more affordable – Google’s Cardboard VR headset is an inexpensive way to experience virtual reality on a smartphone, for example.

WinQuik looks like it will make great gains before the end of the year. The creator of WinQuik, ClickStream, made a November 2020 announcement that they were entering Phase Two of its business plan by launching a mobile marketing campaign. The ads, featuring Pooch Hall and Amber Theoharis, will appear on Facebook, YouTube, Instagram, and other digital platforms. The online trivia gaming platform looks towards a rosy future in 2021. ClickStream also recently announced that, in the first four weeks after its launch, more than 21,000 1-vs-1 challenges have been played on the trivia gaming platform; nearly 2500 participants were repeat players. The company predicts the number of 1-vs-1 challenges in the platform’s first month will outpace early estimates by a long shot.

Some companies are innovating how they deliver existing games to new audiences. Rush Street Interactive (RSI) is one of the fastest-growing online casino gaming companies because of its innovative approaches to creating and operating online gaming products and social casino sites that offer real money prizes. RSI has recently announced its partnership with NetEnt Group, becoming the first online casino operator in the US to premier some of Red Tiger’s most popular titles, such as Gonzo’s Quest™ MegaWays™ and Cash Volt.

Other companies are providing immersive experiences for gamers. For example, Hopa Canada New Online Casino now offers the award-winning augmented reality game, Monopoly Live, which mixes video game graphics with real-life interactions with real-life dealers to gives gamers the feeling they are playing in a casino.  A few companies are collecting data to help them gain a better understanding of what gamers will want in the future.

While it is hard to know exactly what 2021 will bring, it is fairly easy to predict that online gaming will become even more popular in the upcoming year. Companies brave enough to think outside the box will likely attract the most attention (and money) with innovative hardware, expanded platforms, and ingenious advertising approaches.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

SOURCES:

https://www.reuters.com/article/esports-business-gaming-revenues/report-gaming-revenue-to-top-159b-in-2020-idUSFLM8jkJMl

https://www.apple.com/apple-arcade/

https://www.minecraft.net/en-us/about-earth

https://www.levelex.com/

https://zwift.com/

https://www.onepeloton.com/

https://www.oculus.com/quest-2/?locale=en_US

https://arvr.google.com/cardboard/get-cardboard/

http://www.itnewsonline.com/news/ClickStreams-WinQuik-App-to-Enter-Phase-Two-of-Business-Plan-With-Launch-of-Digital-Marketing-Campaign-Featuring-Hosts-Pooch-Hall-and-Amber-Theoharis/1946

https://www.streetinsider.com/Accesswire/ClickStream+Shatters+1-vs-1+Trivia+Challenge+Feature+Projections%2C+Topping+Over+21%2C000+Games+Played+in+First+Month/17604660.html

https://rushstreetgaming.com/interactive/

https://www.businesswire.com/news/home/20201124005552/en/Rush-Street-Interactive-Announces-Third-Quarter-2020-Results-and-Raises-Full-Year-Guidance

https://www.prnewswire.com/news-releases/rush-street-interactive-partners-with-netent-group-to-debut-in-the-united-states-online-casino-games-from-its-red-tiger-game-studio-301177104.html

https://ca.hopa.com/live-casino

Covid-19 Fall Sports…

Covid-19 Pandemic Affecting Fall Sports

The Coronavirus Covid-19 pandemic has changed how Americans do business – it has also affected how we play.

Many organized sports took a hiatus during the spring and summer as players, organizers, public health officials, and fans looked for ways to play safely, and are now trying to squeeze out a fall schedule. For example, soccer is a patchwork of canceled games, limited practices, and normal seasons… at least for now, as COVID-19 flare-ups may dash the dreams of players of all ages.

The decision to play has been especially difficult at the high school level. Most states have canceled high school basketball championships and spring seasons, for example, even before the start of school. Football was a different story, though. Football is a beloved fall tradition and, for pros and amateurs alike, marks the beginning of sports season. The decision whether to nix the fall season has been a controversial and often divisive one – nearly everyone wants football to return, but many wondered how to do it safely.

Twenty-five states had already kicked off their high school football season by September 17, and nine more planned to start their seasons in the fall. By then, a number of states and the District of Columbia said they would push their seasons back to 2021. Colorado had announced they would offer football in both fall and spring. Michigan had reversed their decision twice, moving football from fall to spring on August 14 then moving it back to fall on September 3,2020.

The pandemic has also tripped up recruiting efforts, particularly for high school seniors. High school sport seasons provide athletes with an opportunity to score scholarships that could change the course of their lives. In a typical year, young athletes have several chances to impress college scouts, but 2020 is anything but typical – the pandemic prevents coaches and prospects from traveling to meet in person, and it led to the cancelation of exposure camps normally held in late summer and early autumn.

Fall Sports at the Collegiate Level

On September 22, 2020, the NCAA announced that a number of college sports would hold their 2020 fall championships in the spring of 2021. Sports included are men’s and women’s soccer, men’s and women’s cross-country, women’s volleyball, field hockey, and men’s water polo. They will cap bracket sizes at 75 percent of normal capacity, predetermine championship sites, and reduce the number of preliminary-round sites to support health and safety. While the NCAA has halted most college sports for the fall season, college football goes on. Mid-American Conference (MAC) announced their return on September 25, 2020, which means all 10 Football Bowl Subdivision (FBS) conferences are now competing in the fall. They committed to playing a 6-game conference-only schedule running from November 4th through December 18 or 19, with the MAC championship game. To keep players safe, MAC implemented COVID-19 testing protocols that call for four COVID tests per week, starting October 5. MAC is not allowing general public attendance or tailgating; Conference protocols will guide participation of any Marching Bands, Dance, Cheer and Spirit Squads at football games according to institutional discretion and public health guidance. MAC’s announcement cited the availability of COVID-19 tests and the quick turnaround time of test results across the Conference as leading to the decision to play.

Big Ten recently announced it would start its season on October 24, 2020, prompting 90 teams to attempt playing a full schedule this fall. The ACC, Big 12 and SEC as the Power 5 conferences will also try to play this fall, as will the American, Conference USA and Sun Belt.

Pro Sports During the Pandemic

Professional football is on in full force this fall, with the NFL planning to play a complete schedule. Just one year after celebrating the NFL’s 100th season in grand fashion, this year will feature mostly empty stadiums and canned cheers, officials and coaches in masks, the wearing of tracking devices for contact tracing, daily testing, socially distant meetings, and other protocols to keep fans and players safe. Players who test positive are placed on the reserve/COVID list. On September 26, Atlanta Falcons cornerback A.J. Terrell became the first player to be sidelined after a positive COVID-19 test.

It is hard to know how the pandemic will affect athletes and fans as we move from autumn to winter, but rest assured, the world of sports may never be the same.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

This image has an empty alt attribute; its file name is frankmagliochetti_FrankMagliochettiNews.jpg
Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Sources

https://www.maxpreps.com/news/qiL5GOXkFkyfJ9jwZ8wb-g/where-the-start-of-high-school-sports-stands-in-all-50-states-amid-pandemic.htm

https://www.maxpreps.com/news/ha3S_dWexUOaekUFjBMfkA/high-school-football-kickoff-dates-in-all-50-states.htm

https://www.ncaa.com/live-updates/ncaa/ncaa-sports-news-schedule-changes-coronavirus-updates-all-sports

https://getsomemaction.com/news/2020/9/25/football-maction-is-back.aspx

https://www.nfl.com/news/falcons-cb-a-j-terrell-tests-positive-for-covid-19-placed-on-reserve-list

Fall is Here – What Does This Season Mean for Covid-19

Fall is Here – What does this Mean for Covid-19 in the US and Abroad?

Officials had hoped that the number of coronavirus cases would decline over the summer; since case numbers did not drop, many health professionals are worried that case numbers will spike across the United States and in other nations. In fact, the director of the Centers for Disease Control and Prevention (CDC) warned that country could be facing “the worst fall, from a public health perspective, we’ve ever had.”

There were more than 22,526,000 confirmed cases of COVID-19 worldwide as of August 20, 2020, according to Johns Hopkins University, and 5,567,955 of those cases were in the United States. With vaccine still months away, a number of factors could affect whether the number of cases will increase or decrease into autumn.

On August 13, 2020, the CDC predicted that the number of new cases could decrease into early September. The CDC used several models to make this prediction; many of the models base their assumptions on whether current interventions, such as social distancing, will continue into the fall. The CDC has not yet offered a prediction for the number of COVID-19 cases for autumn, but the federal agency does offer a reminder that the second and more deadly wave of the 1918 pandemic occurred in the fall.

Factors that could affect COVID-19 cases in the US and abroad

The rise or fall of COVID-19 cases in autumn will depend on a number of factors, including the onset of flu season, the use of social distancing and facemasks, the proportion of students returning to in-person classes rather than distance learning, the return to amateur, college and professional sports, and the development of a vaccine.

Unless cases drop dramatically in the next few weeks, the coronavirus outbreak will likely coincide with the flu season, which means the number of sick people could overwhelm an already-stressed healthcare system. Flu season typically starts in October and worsens through January and February. While flu vaccinations could help reduce the burden on healthcare systems, only about 45 percent of American adults received a flu vaccine during last year’s during the 2018–19 flu season, according to the CDC.

Mask wearing is common and culturally acceptable in many parts of the world, particularly in East Asia, but not so in the United States. About 63 percent of people in Japan wore masks during the pandemic, for example, but a July Gallup poll found that only 44 percent of American adults said they “always” wear a mask when outside their homes.

Opening Schools During Covid-19 Pandemic

Opening schools poses a challenge in the US and abroad – while education is essential, in-person learning could cause a spike in infection rates. During the first few months of the pandemic, children seemed to have a much lower infection rate than did adults, but a recent collaborative report by the American Academy of Pediatrics and the Children’s Hospital Association showed that there was a 24 percent increase in child cases between July 30th and August 13th.

Europe’s flattened curve and lower infections rates tempted officials to open schools, but it has not gone as planned. All of Germany’s northeastern state of Mecklenburg-Western Pomerania’s schools opened at the beginning of August, for example, but two schools shut down at the end of the first week infections; the use of masks in schools is preferred but not mandatory.

Schools never closed in Sweden and administrators never major adjustments to class size, lunch policies, or recess rules. This would have been a perfect opportunity to study schools’ role in the spread of the virus; unfortunately, officials never tracked infections among schoolchildren, even when outbreaks led to the closure of individual schools or when staff members died of coronavirus.

Fall Sports During The Covid-19 Pandemic

Fall sports provide ample opportunities for transmission, in that most sports involve close contact between players and the physical exertion associated with sports make mask-wearing difficult. To reduce the risk of transmission, many US high schools are canceling or rescheduling fall sports programs, but Florida and several other states intend to resume as planned. Guidance from the National Federation of State High School Associations (NFHS) may help inform decisions about reopening athletic activities in schools while keeping transmission rates low.

The NFL and a number of professional sports teams plan to start their regular seasons, but with some adjustments to lower risk of transmission, such as frequent testing and phased ramp-up to the regular season. The protocols put in place by the NFL, such as daily testing, banning fans at camp and canceling preseason games, seem to be holding for now – that may change as the season opens, however.

It will be difficult to predict the effects of reopening schools and resuming sports will have on the number of COVID-19 infections or deaths, especially in the absence of social distancing, masks, and a vaccine. In the next installment, we’ll take a look at how the number of COVID-19 cases changed over the fall season and predict what will happen with the approach of winter.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

SOURCES:

https://www.webmd.com/coronavirus-in-context/video/robert-redfield

https://coronavirus.jhu.edu/

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/forecasts-cases.html

https://github.com/cdcepi/COVID-19-Forecasts/blob/master/COVID-19_Forecast_Model_Descriptions.md#JHU

https://www.cdc.gov/flu/pandemic-resources/1918-commemoration/three-waves.htm

https://www.cdc.gov/flu/fluvaxview/coverage-1819estimates.htm

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237691

https://news.gallup.com/poll/315590/americans-face-mask-usage-varies-greatly-demographics.aspx

https://www.cdc.gov/mmwr/volumes/69/wr/mm6932e3.htm

https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/

https://fortune.com/2020/08/10/covid-schools-reopening-class-children-coronavirus/

https://www.sciencemag.org/news/2020/05/how-sweden-wasted-rare-opportunity-study-coronavirus-schools

https://www.maxpreps.com/news/qiL5GOXkFkyfJ9jwZ8wb-g/where-the-start-of-high-school-sports-stands-in-all-50-states-amid-pandemic.htm

https://www.nfhs.org/media/3812287/2020-nfhs-guidance-for-opening-up-high-school-athletics-and-activities-nfhs-smac-may-15_2020-final.pdf

https://www.espn.com/nfl/story/_/id/29548681/2020-nfl-preseason-schedule-training-camp-other-key-dates

https://www.nfl.com/news/nfl-training-camp-amid-covid-19-pandemic-what-you-need-to-know

Innovations in Genetic Testing

Genetic Testing Innovations

Genetic testing is quickly becoming a cornerstone of healthcare, with new medical technologies and innovations enhancing how scientists work with genetics. Gene therapy, simplified genetic tests, and analysis of fully sequenced genomes are just some of the genetic testing innovations improving healthcare today and tomorrow.

The global genetic testing market has consistently risen over the past few years. This rise is fueled by the increasing prevalence of genetic disorders and growing awareness about the benefits of genetic testing. In fact, the global genetic testing market will likely reach 22.834 billion USD in 2024, registering 11.50 percent CAGR throughout the assessment period (2019-2024), according to Market Research Future.

Genetic testing involves a set of laboratory tests that study the patient’s genetic makeup, and identify any gene mutations or alterations in the patient’s DNA that could potentially lead to the development of genetic disorders. Healthcare professionals can use genetic tests to confirm or rule out a suspected genetic disorder. Genetic testing can also help determine the probability that an individual will develop a genetic disorder or pass one down to the next generation.

Types of Genetic Testing and Innovations

As of August 2017, there were about 10,000 unique genetic test types, and approximately 75,000 genetic tests on the market including direct-to-consumer (DTC) genetic tests like 23andMe – more are under development every year. The general types of genetic tests include:

Newborn testing – used just after birth to detect genetic disorders early, when they are easiest to treat

Diagnostic testing – identifies or rules out a specific genetic condition

Carrier testing – identifies people who carry one copy of a gene mutation that, when coupled with another gene with the same mutation, causes a genetic disorder; this test can help couples determine their risk for having a child with a genetic disorder

Prenatal testing – offered during pregnancy if there is a chance that the baby will have a genetic disorder, prenatal testing detects changes in a fetus’s genes prior to birth

Pre-implantation testing – used to detect changes in embryos created through in-vitro fertilization or other assisted reproductive technology to reduce the risk of having a child with a specific genetic disorder

Predictive and presymptomatic testing – detect gene mutations associated with conditions that develop after birth or even later in life; helpful for people whose family member has a genetic condition, but who have no signs or symptoms of the condition at the time of testing

Forensic testing – uses DNA sequences to identify someone for legal purposes, such as identifying victims of a crime or catastrophe, rule out or implicate a suspect in a crime, or to establish paternity or other biological relationship

Genetic Testing Delivery Systems

Innovations in genetic testing involve new delivery systems, finding new genetic variants, and finding new uses for genetic therapies. Researchers from Fred Hutchinson Cancer Research Center recently started using gold nanoparticles as a scalable delivery vehicle for their CRISPR systems, for example, instead of the “old fashioned” approach of using electric shock or viral vectors to deliver genetic editing tools to DNA.

Another group of researchers analyzed coding genes from nearly 46,000 people to identify four genes that contained rare genetic deviations linked to type 2 diabetes. Pharmaceutical companies could use these genes and the proteins they encode as targets for new diabetes medications and treatments.

Doctors in the United States have begun using CRISPR gene-editing therapy to treat cancer patients for the first time. The University of Pennsylvania is following the first two patients in the country to undergo the new therapy – one with sarcoma and one with multiple myeloma, whose cancers did not respond to conventional treatment.

Genetic testing could even help scientists understand COVID-19; they currently use genetic testing known as RNA or PCR tests, to detect the disease.

genetic testing and innovations clinical trials

The tsunami of gene therapy clinical trials underway right now will create a flood of data, particularly in oncology. Oncology is an area that currently represents a quarter of Phase I and Phase II trials. Much of the push to expand genetic testing will come from the consumers themselves. Patients are currently pushing to expand genetic testing beyond its current confines of rare diseases to cover common conditions, such as Parkinson’s disease. In cases in which insurance does not cover the costs of these tests, patients may seek to enroll in clinical trials. When genetic testing is not affordable or accessible, consumers will turn to at-home genetic testing.

FRANK MAGLIOCHETTI

Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Frank is also CEO of ClickStream, ClickStream’s business operations are focused on the development and implementation of WinQuik™, a free to play synchronized mobile app and digital gaming platform. The platform is designed to enable WinQuik™ users to have fun, interact and compete against each other in order to win real money and prizes. Twitter at @ClickstreamC and @WinQuikApp.

Genetic Industry

Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

Frank Magliochetti News is developing Genetic Innovation News.com the site is devoted to genetic innovations; we encourage contributors – the site wants to broadcast your news, discoveries,and innovations.

Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

SOURCES:

https://www.marketresearchfuture.com/reports/genetic-testing-market-2009

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987210

https://www.genome.gov/dna-day/15-ways/direct-to-consumer-genomic-testing

https://www.23andme.com/

https://ghr.nlm.nih.gov/primer/testing/uses

https://www.nature.com/articles/s41563-019-0385-5

https://www.nature.com/articles/s41586-019-1231-2

https://www.the-scientist.com/news-opinion/sars-cov-2-spike-protein-shares-sequence-with-a-human-protein-67596

https://asm.org/Articles/2020/April/COVID-19-Testing-FAQs

https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/gene-therapy-coming-of-age-opportunities-and-challenges-to-getting-ahead

Covid -19: The Race for a Vaccine

The Race for a Vaccine: Covid-19

The race to save lives is underway. Scientists all over the world are speeding to develop a vaccine for COVID-19, a disease that has claimed more than half a million lives worldwide, and hs sickened millions of others. Vaccine development usually takes 10 to 15 years, and the long, involved process takes a tremendous amount of public and private involvement. At the current rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections that cause COVID-19 disease, though, the world does not have 10 to 15 years to wait.

COVID-19 Race for a vaccine

On July 18, 2020, the World Health Organization (WHO) reviewed 23 candidate vaccines in clinical evaluation. Many were still in Phase 1 to establish their safety and dosage at the time of the WHO review, while others were in Phase 2 to establish their performance under ideal and controlled performance. As of that mid-July WHO review, three clinical trials had entered Phase 3 for testing on large numbers of people, although one vaccine trial had not yet recruited candidates.

Why Must We Wait So Long?

Most vaccines in development never make it to licensing – in fact, many vaccine candidates never make to clinical evaluation on real humans because they fail to produce the desired immune response in the pre-clinical stages of testing in cell cultures and lab animals.

Regulators set a high bar for vaccination approval and often require years’ worth of safety data because, unlike medicines that treat diseases, vaccines are administered to healthy people to prevent illness. Releasing a vaccine could potentially do more harm than good, so many regulatory bodies set stiff guidelines for approval.

covid-19-race for A CURE

It is not yet clear what data federal regulators would accept as proof that a vaccine is safe and successful in the middle of the pandemic. On June 30, 2020, the U.S. Food and Drug Administration (FDA) said a vaccine must prevent COVID-19 or decrease the severity of illness in at least 50 percent of people who receive the vaccine. The FDA may consider some vaccine candidates for its Accelerated Approval pathway, but that the vaccine candidate must demonstrate an identifiable immune response or other measure that shows it is reasonably likely that the vaccine would provide clinical benefit. Regulators in other nations have not yet announced what they would consider acceptable criteria for approval, which creates a challenge for vaccine makers trying to gain approval.

More Challenges for Vaccine Makers

Vaccine makers also face challenges determining the best way to trigger the immune response. Vaccines typically work by exposing the body to the antigens of a particular pathogen to activate the immune system without causing disease. Made with weakened or inactivated form of the pathogen, these vaccines are often difficult to develop and produce quickly. Because of the urgent nature of the pandemic, researchers are looking for innovating ways to introduce antigens and otherwise activate an immune response to SARS-CoV-2. Four of the 23 vaccine candidates in clinical testing use an approach that involves engineering messenger RNA (mRNA) that tells human cells how to create the antigens themselves.

RACE FOR A VACCINE COVID-19

Moderna is one of those four companies. On July 15, 2020, the biotech company published data from an early-stage trial that shows its vaccine caused patients to generate an immune response by developing antibodies, although it caused some side effects. Supported by the National Institutes of Health, the study showed volunteers who receive the vaccine produced substantially more neutralizing antibodies than do most patients who have recovered from COVID-19. A second injection administered four weeks after the initial vaccination was necessary to produce a dramatic immune response. Vaccine experts were not impressed, however, concerned that the data was long on text and short on proof.

Other research teams, such as University of Oxford/AstraZeneca are using viral vector vaccines to speed up the process. Viral vector vaccines use a harmless virus as a kind of Trojan horse that carries the pathogen’s genetic material into cells in order to trigger an immune response. The team released more information about its coronavirus vaccine candidate, AZD1222, on July 20, 2020.

Developing a COVID-19 vaccine will be one of the most exciting and important events in human history, with the potential to save millions of lives around the world. Join us next month when we review the next leg of the race for a COVID-19 vaccine.

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Frank Magliochetti owes his professional success to his expertise in two areas: medicine and finance. After obtaining a BS in pharmacy from Northeastern University, he stayed on to enroll in the Masters of Toxicology program. He later specialized in corporate finance, receiving an MBA from The Sawyer School of Business at Suffolk University. His educational background includes completion of the Advanced Management Program at Harvard Business School and the General Management Program at Stanford Business School. Frank Magliochetti has held senior positions at Baxter International, Kontron Instruments, Haemonetics Corporation, and Sandoz. Since 2000, he has been a managing partner at Parcae Capital, where he focuses on financial restructuring and interim management services for companies in the healthcare, media, and alternative energy industries. Last year, he was appointed chairman of the board at Grace Health Technology, a company providing an enterprise solution for the laboratory environment. Most recently; Frank was appointed Chairman and Chief Executive Officer at Designer Genomics International, Inc. The Company has accumulated a growing body of evidence that highlights a link between alterations in the immune and inflammatory systems and the development of chronic human disease. The Company is visionary and has established itself as a leader in the field of inflammatory and immune genetic DNA and RNA biomarkers that play a causative role in debilitating conditions, such as atherosclerosis/heart disease, diabetes, arthritis, inflammatory bowel disease, post-traumatic stress disorders (PTSD) and cancer.
A proprietary state-of-the art data mining bioinformatics program, called ‘cluster analysis’ will be used to measure disease development susceptibility with potential for earlier diagnosis and intervention. The company is developing a healthcare program based on its proprietary genetic panels that will allow people to be their own healthcare advocate and take an active role in their health status as well as longevity.

Mr. Frank Magliochetti MBA
Managing Partner
Parcae Capital

www.parcaecapitalcorp.com
www.frankmagliochetti.com

Sources

https://coronavirus.jhu.edu/map.html

https://www.historyofvaccines.org/content/articles/vaccine-development-testing-and-regulation

https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines

https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-takes-action-help-facilitate-timely-development-safe-effective-covid

https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/accelerated-approval

https://www.nejm.org/doi/full/10.1056/NEJMoa2022483

https://www.astrazeneca.com/media-centre/press-releases/2020/astrazeneca-and-oxford-university-announce-landmark-agreement-for-covid-19-vaccine.html